394815

N-Maleoyl-β-alanine

97%

• Sinônimo(s): 3-Maleimidopropionic acid, N-(2-Carboxyethyl)maleimide
• Fórmula empírica (Notação de Hill): C₇H₇NO₄
• Número CAS: 7423-55-4
• Peso molecular: 169.13
• Beilstein: 1528952
• Número MDL: MFCD00043030
• Código UNSPSC: 12352100
• ID de substância PubChem: 24864618
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• Ensaio: 97%
• Formulário: powder
• pontuação do produto alternativo mais ecológico: old score: 18; new score: 7; Find out more about DOZN™ Scoring
• características do produto alternativo mais ecológico: Less Hazardous Chemical Syntheses; Safer Solvents and Auxiliaries; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• pf: 103-106 °C (lit.)
• grupo funcional: carboxylic acid; imide; maleimide
• categoria alternativa mais ecológica: , Re-engineered
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC(=O)CCN1C(=O)C=CC1=O
• InChI: 1S/C7H7NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-2H,3-4H2,(H,11,12)
• chave InChI: IUTPJBLLJJNPAJ-UHFFFAOYSA-N

Descrição

Descrição geral

N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Less Hazardous Chemical Syntheses”, "Safer Solvents and Auxiliaries" and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Aplicação

N-Maleoyl-β-alanine (3-maleimidopropanoic acid, N-(2-carboxyethyl)maleimide)) is the suitable reagent used in the following studies:

• To decrease the biotin binding affinity of Avd(S16C) (avidin with a single point mutation S16C).
• As a side chain reactive agent to modify tryptic peptides that result in mass shifts indicating the presence of cysteine residues.
• To preblock Xenopus laevis oocytes for exposed cysteines used as an expression system in the study of conformational changes in cASIC1a Receptors.

It may be used in the following studies:

• As a protective agent for keratin fiber in high temperature process.
• As a non-cleavable maleimido moiety during the synthesis of tetrawalled molecular umbrella-octaarginine conjugates.
• Synthesis of organotin carboxylates of N-Maleoyl-β-alanine.
• To functionalize the gold surfaces to interact with cysteine-modified peptide.
• Preparation of cross-linked dextran–poly(ethylene glycol) hydrogel substrate.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves