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284262

Sigma-Aldrich

Iodoacetic anhydride

Sinônimo(s):

2-Iodoacetic anhydride, 2-Iodoacetyl 2-iodoacetate, Iodoacetic acid anhydride, Iodoacetyl anhydride

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About This Item

Fórmula linear:
(ICH2CO)2O
Número CAS:
54907-61-8
Peso molecular:
353.88
Beilstein:
1812140
Número MDL:
MFCD00001080
Código UNSPSC:
12352100
ID de substância PubChem:
24857144
NACRES:
NA.22

Formulário

solid

Nível de qualidade

100

pf

47-49 °C (lit.)

solubilidade

chloroform: soluble 10%, clear to slightly hazy, yellow (pink or tan)

grupo funcional

anhydride
ester
iodo

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

ICC(=O)OC(=O)CI

InChI

1S/C4H4I2O3/c5-1-3(7)9-4(8)2-6/h1-2H2

chave InChI

RBNSZWOCWHGHMR-UHFFFAOYSA-N

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Aplicação

Reagent used as linker for development of reagents used for differential protein quantitation via ion scanning

Reactant used for:
  • Sythesis of N-iodoacetyl glycosylamine derivatives and converting amino precursors to IA derivatives
  • Linking lysine residues to N-terminal α-amino groups of peptides
  • Capping amines and yielding a thiol reactive iodo-derivative
  • Iodoacetylation

Pictogramas

Skull and crossbonesCorrosion
GHS06,GHS05

Palavra indicadora

Danger

Frases de perigo

H301,H314

Classificações de perigo

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

230.0 °F - closed cup

Ponto de fulgor (°C)

110 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
MKCN7161
MKCH2071
MKCF3081
MKCC5307
MKBX9896V

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Sigma-Aldrich

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Iodoacetamida

M W Reed et al.
Bioconjugate chemistry, 6(1), 101-108 (1995-01-01)
An endogenous nuclear enzyme, RNase H, is an important component in determining the efficacy of antisense oligodeoxynucleotides (ODNs). In an effort to improve the potency of antisense ODNs, conjugates with three different nuclear targeting signal peptides were prepared. These short
S J Wood et al.
International journal of peptide and protein research, 39(6), 533-539 (1992-06-01)
A novel method is described for the cyclization of peptides--or segments of polypeptides--which requires a free N-terminal alpha-amino group and a distal amino acid residue containing a nucleophilic side chain. The reaction is conducted in two steps, both in the
Rainer Hahn et al.
Journal of chromatography. A, 1217(40), 6203-6213 (2010-08-31)
To design a generic purification platform and to combine the advantages of fusion protein technology and matrix-assisted refolding, a peptide affinity medium was developed that binds inclusion body-derived N(pro) fusion proteins under chaotropic conditions. Proteins were expressed in Escherichia coli
S J Wood et al.
Bioconjugate chemistry, 3(5), 391-396 (1992-09-01)
We describe a new method for the transfer of carbohydrate moieties to polypeptides in which complex carbohydrate, in the form of glycosyl amino acid, is removed from an available glycoprotein, derivatized, and reacted with a polypeptide via an iodoacetylated alpha-amino
R Wetzel et al.
Bioconjugate chemistry, 1(2), 114-122 (1990-03-01)
A method is described for the highly selective modification of the alpha-amino groups at the N-termini of unprotected peptides to form stable, modified peptide intermediates which can be covalently coupled to other molecules or to a solid support. Acylation with

Global Trade Item Number

SKUGTIN
284262-1G4061826071953
284262-250MG4061832491684

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