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191884

Sigma-Aldrich

Hydroxypropyl cellulose

average Mw ~100,000, powder, 20 mesh particle size (99% through)

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About This Item

Número CAS:
9004-64-2
Número MDL:
MFCD00132688
Código UNSPSC:
12162002
NACRES:
NA.23

descrição

biological oxygen demand (BOD) 14,000 ppm

Formulário

powder

temperatura de autoignição

752 °F

peso molecular

average Mw ~100,000

Impurezas

<5 wt. %

tamanho de partícula

20 mesh (99% through)

pH

5.0-8.5

tensão interfacial do óleo mineral

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosidade

65-175 cP, 5 wt. % in H2O(25 °C, Brookfield, spindle #1) (30 rpm)(lit.)

solubilidade

polar organic solvents: soluble

densidade

0.5 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

chave InChI

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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Descrição geral

Hydroxypropyl cellulose (HPC) is a neutral polysaccharide prepared by reacting propylene oxide with alkali cellulose at high temperatures and pressure. It is soluble in water and many polar organic solvents. HPC is widely used as a food additive and in drug delivery systems.

Aplicação

Hydroxypropyl cellulose can be used in the following applications:
  • HPC is soluble in organic solvents which makes it suitable for the preparation of polymer gel electrolytes for electrochemical devices. The network-forming ability of HPC can improve the mechanical and electrical properties of gel electrolytes.
  • Electrospun hydroxypropyl cellulose nanofibres can be used to develop drug delivery systems for a variety of hydrophobic drugs.
  • Hydroxypropylcellulose combined with an effervescent agent like sodium carbonate can be usedas a binder and functional material to prepare floating tablets for thecontrolled release of ofloxacin.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
MKCP0086
MKCN9507
MKCN1103
MKCL9954
MKCK3356

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Jeremiah F Kelleher et al.
AAPS PharmSciTech, 21(1), 23-23 (2019-12-14)
The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the
Daniela M Correia et al.
Materials (Basel, Switzerland), 13(10) (2020-05-21)
This study reports a versatile method for the development of cellulose nanocrystals (CNCs) and water-soluble cellulose derivatives (methyl cellulose (MC), hydroxypropyl cellulose (HPC), and sodium carboxymethyl cellulose (NaCMC)) films comprising the ionic liquid (IL) 2-hydroxy-ethyl-trimethylammonium dihydrogen phosphate ([Ch][DHP]) for actuator
Jianjun Yang et al.
International orthopaedics, 37(3), 515-521 (2012-11-28)
The aim of this study was to determine whether hydroxypropylcellulose (HPC) coating of polyethylene terephthalate (PET) artificial ligaments enhances graft osseointegration in the bone tunnel. Thirty New Zealand white rabbits underwent artificial ligament graft transplantation in the bilateral proximal tibia
Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via
Maya Fujiwara et al.
Chemical & pharmaceutical bulletin, 60(11), 1380-1386 (2012-11-06)
We evaluated models for predicting spray mist diameter suitable for scaling-up the fluidized bed granulation process. By precise selection of experimental conditions, we were able to identify a suitable prediction model that considers changes in binder solution, nozzle dimension, and
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