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Key Documents

SML1065

Sigma-Aldrich

TR100

≥98% (HPLC)

Synonym(s):

2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide

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About This Item

Empirical Formula (Hill Notation):
C26H38N4O
CAS Number:
Molecular Weight:
422.61
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=C(/C=C(C#N)\C(NCCCCCCCC)=O)C2=C(N1CCCN(C)C)C=CC=C2

InChI

1S/C26H38N4O/c1-5-6-7-8-9-12-16-28-26(31)22(20-27)19-24-21(2)30(18-13-17-29(3)4)25-15-11-10-14-23(24)25/h10-11,14-15,19H,5-9,12-13,16-18H2,1-4H3,(H,28,31)/b22-19-

InChI key

XXRLIGWROLDOLS-QOCHGBHMSA-N

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Show Differences

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This Item
SML1217SML0204SML0248
TR100 ≥98% (HPLC)

SML1065

TR100

TG4-155 ≥98% (HPLC)

SML1217

TG4-155

MS-1020 ≥98% (HPLC)

SML0204

MS-1020

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥10 mg/mL at 60 °C

solubility

DMSO: ≥5 mg/mL

color

white to beige

color

white to beige

color

white to tan

color

white to beige

Biochem/physiol Actions

TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. TR100 induces apoptosis in a panel of neural crest-derived tumor cell lines with no adverse effects on cardiac structure and function.

hcodes

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Katharina Baron et al.
PloS one, 11(11), e0164284-e0164284 (2016-11-11)
Quantitative magnetic resonance imaging (qMRI) offers several advantages in imaging and determination of soft tissue alterations when compared to qualitative imaging techniques. Although applications in brain and muscle tissues are well studied, its suitability to quantify relaxation times of intact

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