D6003

Supelco

Digoxin

analytical standard

Synonym(s):
12β-Hydroxydigitoxin
Empirical Formula (Hill Notation):
C41H64O14
CAS Number:
Molecular Weight:
780.94
Beilstein/REAXYS Number:
77011
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

biological source

plant (Digitalis lanata)

grade

analytical standard

assay

≥95.0% (HPLC)

form

neat

application(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

methanol: methylene chloride (1:1): 0.5%, clear, colorless

Featured Industry

Food and Beverages
Forensics and Toxicology
Veterinary

format

neat

functional group

ketone

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4

InChI

1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

InChI key

LTMHDMANZUZIPE-PUGKRICDSA-N

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Application

Digoxin may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

100 mg in glass bottle
1, 5 g in glass bottle

Biochem/physiol Actions

A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC
Varma.S.V M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 813(1-2), 347-352 (2004)
Combined liquid chromatography/radioimmunoassay with improved specificity for serum digoxin
Gault H.M, et al.
Clinical Chemistry, 31(8), 1272-1277 (1985)
Andrew Nickless et al.
Nature medicine, 20(8), 961-966 (2014-07-30)
The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant transcripts containing premature translation termination codons and regulates the levels of a number of physiological mRNAs. NMD modulates the clinical outcome of a variety of human diseases, including cancer and many...
Adriana Katz et al.
The Journal of biological chemistry, 289(30), 21153-21162 (2014-06-12)
In the ciliary epithelium of the eye, the pigmented cells express the α1β1 isoform of Na,K-ATPase, whereas the non-pigmented cells express mainly the α2β3 isoform of Na,K-ATPase. In principle, a Na,K-ATPase inhibitor with selectivity for α2 could effectively reduce intraocular...
Chuan-Ming Xie et al.
Carcinogenesis, 34(8), 1870-1880 (2013-04-26)
Cardiac glycosides as inhibitors of the sodium/potassium adenosine triphosphatase (sodium pump) have been reported to block cancer growth by inducing G2/M phase arrest in many cancer cells. However, no detailed studies have been performed to distinguish between these two phases...
Protocols
LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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