P7791

Prazosin hydrochloride

≥99.0% (HPLC)

• Synonym(s): 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₁N₅O₄ · HCl
• CAS Number: 19237-84-4
• Molecular Weight: 419.86
• Beilstein: 4303561
• EC Number: 242-903-4
• MDL number: MFCD00058177
• PubChem Substance ID: 24277793
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥99.0% (HPLC)
• form: powder
• solubility: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• originator: Pfizer
• SMILES string: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• InChI key: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Description

General description

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Application

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem/physiol Actions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Hygroscopic; light sensitive.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Warning
• Hazard Statements: H336 - H361fd - H373
• Precautionary Statements: P201 - P202 - P260 - P271 - P280 - P308 + P313
• Hazard Classifications: Repr. 2 - STOT RE 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves