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A8404

Sigma-Aldrich

Amitriptyline hydrochloride

≥98% (TLC), powder

Empirical Formula (Hill Notation):
C20H23N · HCl
CAS Number:
Molecular Weight:
313.86
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: soluble
ethanol: soluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

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Application

Amitriptyline hydrochloride has been used:
  • as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
[40]
  • as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
  • [37]
  • as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse
  • [41]

    Biochem/physiol Actions

    Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia.[58] It possesses antihistaminic, anticholinergic, and antiserotonimic properties.[35] Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.[58]
    Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

    Features and Benefits

    Shelf-life of the powder is at least three years.

    Signal Word

    Danger

    Hazard Classifications

    Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

    Storage Class Code

    6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

    Enter Lot Number to search for Certificate of Analysis (COA).

    Certificate of Origin

    Enter Lot Number to search for Certificate of Origin (COO).

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