D4876

Dextran from Leuconostoc mesenteroides

average mol wt 150,000

• Linear Formula: (C₆H₁₀O₅)_n
• CAS Number: 9004-54-0
• EC Number: 232-677-5
• MDL number: MFCD00130935
• NACRES: NA.25

Properties

• biological source: bacterial (Leuconostoc mesenteroides)
• Quality Level: 200
• form: powder
• optical activity: [α]/D 199°
• mol wt: average mol wt 150,000
• solubility: H₂O: soluble 20 mg/mL

Description

Application

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextran 150 may be used to study iron delivery to cells, cell membrane permeabilization and red blood cell aggregation.

Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

Packaging

50, 100 g in poly bottle

500 g in poly drum

1 kg in poly drum

Preparation Note

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115^oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves