56480
purum
≥97.0% (T)
solid
reaction type: Addition Reactions
95-98 °C (lit.)
95-98 °C
peptide synthesis
ON1C(=O)CCC1=O
1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
NQTADLQHYWFPDB-UHFFFAOYSA-N
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11 - Combustible Solids
WGK 3
Not applicable
Not applicable
dust mask type N95 (US), Eyeshields, Gloves
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In principle, the seemingly simple formation of a peptide bond can be accomplished using all the procedures available in organic chemistry for the synthesis of carboxylic acid amides. However, due to the presence of various functional groups in natural and unnatural amino acids and particularly the requirement for full retention of chiral integrity, the coupling of amino acids and peptides under mild conditions can be challenging. A plethora of coupling reagents has been developed superseding each other in efficiency and suitability for specific applications (e.g., solid-phase peptide synthesis or fragment condensation).
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