T9262

Tamoxifen citrate salt

≥99% (TLC), powder, PKC inhibitor

• Synonim(y): (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
• Wzór empiryczny (zapis Hilla): C₂₆H₂₉NO · C₆H₈O₇
• Numer CAS: 54965-24-1
• Masa cząsteczkowa: 563.64
• Numer WE: 259-415-2
• Numer MDL: MFCD00058321
• Kod UNSPSC: 12161501
• Identyfikator substancji w PubChem: 24278059
• NACRES: NA.77

Właściwości

• product name: Tamoxifen citrate salt, ≥99%
• Poziom jakości: 200
• Próba: ≥99%
• rozpuszczalność: methanol: soluble 50 mg/mL, clear, colorless
• inicjator: AstraZeneca
• temp. przechowywania: 2-8°C
• ciąg SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3
• InChI: 1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• Klucz InChI: FQZYTYWMLGAPFJ-OQKDUQJOSA-N
• informacje o genach: human ... ESR1(2099) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

Opis

Zastosowanie

Tamoxifen has been used for analyzing its effects on radiation sensitivity and steroid receptor content in human breast cancer cells. It has also been used for studying the accumulation of triacylglycerol in hepatic tissues of female rats. Furthermore, studies have reported that environmental magnetic fields can block antiproliferative functions of tamoxifen in human breast cancer cells.

Działania biochem./fizjol.

Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Uwaga dotycząca przygotowania

Tamoxifen citrate salt dissolves in methanol at 50 mg/ml to yield a clear, colorless solution.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H350,H360D,H410
• Zwroty wskazujące środki ostrożności: P201 - P273 - P301 + P312 + P330 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges