T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• Synonim(y): 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• Wzór empiryczny (zapis Hilla): C₂₉H₅₀O₂
• Numer CAS: 59-02-9
• Masa cząsteczkowa: 430.71
• Beilstein: 4712525
• Numer WE: 200-412-2
• Numer MDL: MFCD00072045
• Kod UNSPSC: 12352205
• eCl@ss: 34058016
• Identyfikator substancji w PubChem: 24900154
• NACRES: NA.79

Właściwości

• pochodzenie biologiczne: vegetable oil
• Poziom jakości: 200
• typ: Type V
• Formularz: viscous liquid
• aktywność właściwa: ~1000 IU/g
• kolor: clear yellow to red
• współczynnik refrakcji: n20/D 1.505 (lit.)
• bp: 200-220 °C/0.1 mmHg (lit.)
• gęstość: 0.95 g/mL at 25 °C (lit.)
• temp. przechowywania: −20°C
• ciąg SMILES: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
• Klucz InChI: GVJHHUAWPYXKBD-IEOSBIPESA-N

Opis

Opis ogólny

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Zastosowanie

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

Działania biochem./fizjol.

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Opakowanie

Packaged under argon in a sealed ampule.

Inne uwagi

Mixed constitutional (α, β, γ, δ) isomers.

Jakość

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

Przestroga

Subject to air oxidation.

Właściwości fizyczne

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 230.0 °F - closed cup
• Temperatura zapłonu (°C): 110 °C - closed cup
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)