SAB4300135

Anti-phospho-PAK1/PAK2/PAK3 (pThr⁴²³/pThr⁴⁰²/pThr⁴²¹) antibody produced in rabbit

affinity isolated antibody

• Synonim(y): Anti-ADE2 antibody produced in rabbit, Anti-CDKN1A antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit
• Numer MDL: MFCD02097133
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: 61-67 kDa; 68-74 kDa
• reaktywność gatunkowa: mouse, human, rat
• stężenie: 1 mg/mL
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• izotyp: IgG
• sekwencja immunogenna: (R-S-TP-M-V)
• numer dostępu NCBI: NP_001121638.1; NP_001122092.1; NP_002568.2
• numer dostępu UniProt: Q13177
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: phosphorylation (pThr423/pThr402/pThr421)
• informacje o genach: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

Opis

Immunogen

Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.

Cechy i korzyści

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Opis wartości docelowych

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable