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Merck

PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

Synonyms:
CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Species:
Human PAK3 (5063), Mouse Pak3 (18481), Rat Pak3 (29433), fruit fly Pak3 (41995), chicken PAK3 (422342), cow PAK3 (534526), Horse PAK3 (100054315), domestic cat PAK3 (101092248), dog PAK3 (492067), sheep PAK3 (101110391) ...More
UniProtKB ID:
O75914, A8K389, B1GX77, B1GX78, B1GX79, Q5JWX1, Q5JWX2, Q7Z2D6
Gene ID:
  • Human(5063) Summary: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(18481) p21 protein (Cdc42/Rac)-activated kinase 3
  • Rat(29433) p21 protein (Cdc42/Rac)-activated kinase 3
  • fruit fly(41995) CG14895 gene product from transcript CG14895-RD
  • chicken(422342) p21 protein (Cdc42/Rac)-activated kinase 3
  • cow(534526) p21 protein (Cdc42/Rac)-activated kinase 3
  • Horse(100054315) p21 protein (Cdc42/Rac)-activated kinase 3
  • domestic cat(101092248) p21 protein (Cdc42/Rac)-activated kinase 3
  • dog(492067) p21 protein (Cdc42/Rac)-activated kinase 3
  • sheep(101110391) p21 protein (Cdc42/Rac)-activated kinase 3
  • Domestic Rabbit(100347273) p21 protein (Cdc42/Rac)-activated kinase 3
  • naked mole-rat(101712811) p21 protein (Cdc42/Rac)-activated kinase 3
  • domestic guinea pig(100721049) p21 protein (Cdc42/Rac)-activated kinase 3

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Antibodies

Product Number
Description
Species Reactivity
Application
07-2101-M
Anti-phospho PIX Antibody (Ser340), from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
western blot
WH0005063M8
Monoclonal Anti-PAK3 antibody produced in mouse, clone 3A12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunofluorescence
western blot
SAB4300135
Anti-phospho-PAK1/PAK2/PAK3 (pThr423/pThr402/pThr421) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

Proteins

Product Number
Description
Species
K3018
PAK3, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse
14-683-M
PAK3 Protein, active, 10 µg, Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.,
Species
human