Przejdź do zawartości
Merck
Wszystkie zdjęcia(2)

Key Documents

View All Documentation

M4910

Sigma-Aldrich

1-Methylhistamine dihydrochloride

≥98% (TLC), powder

Synonim(y):

1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(2)

About This Item

Wzór empiryczny (zapis Hilla):
C6H11N3 · 2HCl
Numer CAS:
6481-48-7
Masa cząsteczkowa:
198.09
Numer MDL:
MFCD00037000
Kod UNSPSC:
12352204
Identyfikator substancji w PubChem:
24277805
NACRES:
NA.32

product name

1-Methylhistamine dihydrochloride, ≥98% (TLC), powder

Poziom jakości

200

Próba

≥98% (TLC)

Postać

powder

rozpuszczalność

water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

temp. przechowywania

2-8°C

ciąg SMILES

Cl[H].Cl[H].Cn1cnc(CCN)c1

InChI

1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H

Klucz InChI

AGXVEALMQHTMSW-UHFFFAOYSA-N

informacje o genach

human ... HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340)

Szukasz podobnych produktów? Odwiedź Przewodnik dotyczący porównywania produktów

Zastosowanie

1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

Działania biochem./fizjol.

1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.
Major metabolite of histamine by histamine N-methyltransferase.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Klienci oglądali również te produkty

Slide 1 of 4

1 of 4

Hypotaurine ≥98% (TLC)

Sigma-Aldrich

H1384

Hypotaurine

Serotonin analytical standard

Supelco

14927

Serotonin

Histamine dihydrochloride ≥99% (TLC), powder

Sigma-Aldrich

H7250

Histamine dihydrochloride

L-(+)-Tartaric acid ACS reagent, ≥99.5%

Sigma-Aldrich

251380

L-(+)-Tartaric acid

Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
Koro Gotoh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(9), 1131-1133 (2005-05-17)
Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior.
Mouhammad Motawaj et al.
Journal of Alzheimer's disease : JAD, 22(3), 861-871 (2010-09-23)
Neuropathological studies have reported a strong neurofibrillary degeneration of the tuberomamillary nucleus, the region of origin of histamine neurons, in Alzheimer's disease (AD). Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of
F Gbahou et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 945-954 (2010-06-10)
We previously suggested that therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). However, H(3)Rs exhibit constitutive activity, and most H(3)R antagonists act as inverse agonists. Here, we have investigated the effects
Yves Dauvilliers et al.
Sleep, 35(10), 1359-1366 (2012-10-02)
To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. sensitive liquid
Wyświetl wszystkie powiązane dokumenty

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej