Przejdź do zawartości
Merck

SMB00939

Sigma-Aldrich

1-Methyladenosine

≥95% (HPLC)

Synonim(y):

1-Methyladenosine, N1-Methyladenosine

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych


About This Item

Wzór empiryczny (zapis Hilla):
C11H15N5O4
Numer CAS:
Masa cząsteczkowa:
281.27
Numer MDL:
Kod UNSPSC:
12352123
NACRES:
NA.79

Poziom jakości

Próba

≥95% (HPLC)

Postać

solid

kolor

white

temp. przechowywania

-10 to -25°C

ciąg SMILES

CN1C=Nc2c(ncn2[C@@H]3O[C@@H](CO)[C@H](O)[C@@H]3O)C1=N

InChI

1S/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3/t5-,7-,8-,11-/m1/s1

Klucz InChI

GFYLSDSUCHVORB-IOSLPCCCSA-N

Szukasz podobnych produktów? Odwiedź Przewodnik dotyczący porównywania produktów

Opis ogólny

1-Methyladenosine is an RNA modification that arises through distinct processes, including enzymatic catalysis and the alkylation of RNA by specific agents.
1-Methyladenosine, also known as M1A, belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. 1-Methyladenosine is a strong basic compound (based on its pKa). Precise m6A mapping by m6A-CLIP/IP (briefly m6A-CLIP) revealed that a majority of m6A locates in the last exon of mRNAs in multiple tissues/cultured cells of mouse and human, and the m6A enrichment around stop codons is a coincidence that many stop codons locate round the start of last exons where m6A is truly enriched. The methylation of adenosine is directed by a large m6A methyltransferase complex containing METTL3 as the SAM-binding sub-unit. Insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1–3) are reported as a novel class of m6A readers.

Zastosowanie

1-Methyladenosine, a modified nucleoside produced during tRNA processing by methyltransferases, has garnered attention as a potential biomarker for early cancer detection due to its elevated urinary excretion in various cancer forms. Additionally, its presence can be monitored in serum. Moreover, 1-Methyladenosine levels rise during active rheumatoid arthritis, making it a promising indicator for this condition. It finds application in research pertaining to cancer, autoimmune diseases, metabolomics, biomarker discovery and drug discovery studies.

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number

Nie widzisz odpowiedniej wersji?

Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej