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Kluczowe dokumenty
C1057
Butyrylcholinesterase from equine serum
lyophilized powder, ≥900 units/mg protein
Synonim(y):
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
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About This Item
Polecane produkty
Formularz
lyophilized powder
Poziom jakości
aktywność właściwa
≥900 units/mg protein
masa cząsteczkowa
tetramer 440 kDa
skład
Protein, ≥10%
rozpuszczalność
H2O: soluble 10 mg/mL
Zastosowanie
diagnostic assay manufacturing
temp. przechowywania
−20°C
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Zastosowanie
Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents. Cholinesterases have also been investigated for their role in Alzheimer′s disease.
Działania biochem./fizjol.
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Definicja jednostki
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
Postać fizyczna
Highly purified; contains buffer salts
Komentarz do analizy
Protein determined by biuret
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Inhibitor
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Resp. Sens. 1
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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