B4186

Butyrylcholinesterase human

vial of ≥4 units

• Synonim(y): Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
• Numer CAS: 9001-08-5
• Numer EC enzymu: 3.1.1.8 (BRENDA, IUBMB)
• Numer WE: 232-579-2
• Numer MDL: MFCD00081455
• Kod UNSPSC: 12352204
• NACRES: NA.54

Właściwości

• Postać: powder
• Poziom jakości: 200
• aktywność właściwa: ≥50 units/mg protein
• opakowanie: vial of ≥4 units
• numer dostępu UniProt: P06276
• temp. przechowywania: 2-8°C
• informacje o genach: human ... BCHE(590)

Opis

Zastosowanie

BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .

Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.

Działania biochem./fizjol.

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates. BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.

Definicja jednostki

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

Komentarz do analizy

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H334
• Zwroty wskazujące środki ostrożności: P261 - P284 - P501
• Klasyfikacja zagrożeń: Resp. Sens. 1
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable