85558

Spermidine

BioUltra, for molecular biology, ≥99.5% (GC)

• Synonim(y): SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Wzór liniowy: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Numer CAS: 124-20-9
• Masa cząsteczkowa: 145.25
• Beilstein: 1698591
• Numer WE: 204-689-0
• Numer MDL: MFCD00008229
• Kod UNSPSC: 12352116
• Identyfikator substancji w PubChem: 57653053
• NACRES: NA.26

Właściwości

• klasa czystości: for molecular biology
• Poziom jakości: 200
• linia produktu: BioUltra
• Próba: ≥99.5% (GC)
• warunki przechowywania: (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
• metody: ChIP: suitable; buffer exchange: suitable
• zanieczyszczenia: DNases, none detected; RNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected
• współczynnik refrakcji: n20/D 1.479 (lit.)
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• rozpuszczalność: H₂O: 1 M at 20 °C, clear, colorless
• gęstość: 0.925 g/mL at 25 °C (lit.)
• ślady anionów: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• ślady kationów: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• absorpcja UV: λ: 260 nm A_max: 0.1; λ: 280 nm A_max: 0.05
• ciąg SMILES: NCCCCNCCCN
• przydatność: suitable for molecular biology
• Zastosowanie: advanced drug delivery; genomic analysis
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Klucz InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• informacje o genach: rat ... Ppm1a(24666)

Opis

Opis ogólny

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Zastosowanie

Spermidine has been used:

• as a component of chromosome isolation buffer
• as a component of transcription buffer
• as a component of homogenization buffer

Działania biochem./fizjol.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

Cechy i korzyści

• Versatile and adaptable for a wide variety of laboratory and research applications
• Suitable for Molecular Biology and Biochemical research
• Free from DNase, RNase, NICKase, and protease
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
• Tested for trace levels of Anions and Cations

Przestroga

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Komentarz do analizy

liquid or solid

Inne uwagi

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In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H314
• Zwroty wskazujące środki ostrożności: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Klasyfikacja zagrożeń: Eye Dam. 1 - Skin Corr. 1B
• Kod klasy składowania: 8A - Combustible corrosive hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 233.6 °F - closed cup
• Temperatura zapłonu (°C): 112 °C - closed cup
• Środki ochrony indywidualnej: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter