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S4264
Spermine
BioReagent, suitable for cell culture
Synonim(y):
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
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About This Item
Wzór liniowy:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Numer CAS:
Masa cząsteczkowa:
202.34
Beilstein:
1750791
Numer WE:
Numer MDL:
Kod UNSPSC:
12352204
Identyfikator substancji w PubChem:
NACRES:
NA.75
Polecane produkty
pochodzenie biologiczne
microbial
synthetic
linia produktu
BioReagent
Próba
≥96%
Formularz
solid
metody
cell culture | mammalian: suitable
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
rozpuszczalność
H2O: 50 mg/mL
temp. przechowywania
2-8°C
ciąg SMILES
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
Klucz InChI
PFNFFQXMRSDOHW-UHFFFAOYSA-N
informacje o genach
human ... GRIN2B(2904)
rat ... Grin2a(24409)
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Zastosowanie
Spermine has been used:
- in the buffer, to swap the divalent cations in the MgSO4 protocol to stabilize the integrity of the chromosomes
- in the preparation of modified mica surfaces from freshly cleaved mica surfaces
- to study its effects on survival in mice with sepsis and to estimate the role of spermine in lethal systemic inflammatory diseases
Działania biochem./fizjol.
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
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Numer produktu
Opis
Cennik
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Dam. 1 - Skin Corr. 1B
Kod klasy składowania
8A - Combustible corrosive hazardous materials
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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