S2626

Spermidine

≥99% (GC)

• Synonim(y): 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Wzór liniowy: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Numer CAS: 124-20-9
• Masa cząsteczkowa: 145.25
• Beilstein: 1698591
• Numer WE: 204-689-0
• Numer MDL: MFCD00008229
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24899529
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• Próba: ≥99% (GC)
• Postać: solid or liquid (clear)
• zanieczyszczenia: DNase, none detected; RNase, none detected; protease, none detected
• współczynnik refrakcji: n20/D 1.479 (lit.)
• mp: 22-25 °C
• rozpuszczalność: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• gęstość: 0.925 g/mL at 25 °C (lit.)
• temp. przechowywania: room temp
• ciąg SMILES: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Klucz InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• informacje o genach: rat ... Ppm1a(24666)

Opis

Opis ogólny

Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.

Zastosowanie

Spermidine has been used:

• in the preparation of 5x transcription buffer
• in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
• as a standard in the analytical study of rat brain polyamines (185)

Działania biochem./fizjol.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Przestroga

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Inne uwagi

Store under inert gas. Air sensitive; strongly hygroscopic.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H314
• Zwroty wskazujące środki ostrożności: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Klasyfikacja zagrożeń: Eye Dam. 1 - Skin Corr. 1B
• Kod klasy składowania: 8A - Combustible corrosive hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 233.6 °F - closed cup
• Temperatura zapłonu (°C): 112 °C - closed cup
• Środki ochrony indywidualnej: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter