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P7505

Sigma-Aldrich

Putrescine dihydrochloride

≥98% (TLC), powder

Synonim(y):

1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride

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About This Item

Wzór liniowy:
NH2(CH2)4NH2 · 2HCl
Numer CAS:
333-93-7
Masa cząsteczkowa:
161.07
Beilstein:
3906680
Numer WE:
206-375-9
Numer MDL:
MFCD00012526
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24278650
NACRES:
NA.77

product name

Putrescine dihydrochloride, ≥98% (TLC)

Próba

≥98% (TLC)

Postać

powder

mp

280 °C (dec.) (lit.)

rozpuszczalność

H2O: soluble 100 mg/mL, clear, colorless

ciąg SMILES

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

Klucz InChI

XXWCODXIQWIHQN-UHFFFAOYSA-N

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Zastosowanie

Putrescine dihydrochloride has been used:
  • as a bioactive amine standard in high-performance liquid chromatography (HPLC)
  • as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
  • as a supplement in DMEM for culturing of endometrial cancer cells

Działania biochem./fizjol.

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesCorrosion
GHS06,GHS05

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H302,H311,H314,H330

Klasyfikacja zagrożeń

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

113.0 °F - closed cup

Temperatura zapłonu (°C)

45 °C - closed cup

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

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Mito Kanatsu-Shinohara et al.
Methods in enzymology, 477, 17-36 (2010-08-12)
Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem
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Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect
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Journal of neuroscience research, 98(7), 1498-1513 (2020-03-14)
The neuroretina is protected by its own defense system, that is microglia and the complement system. Under normal physiological conditions, microglial activation is tightly regulated by the neurons although the underlying mechanism remains elusive. Using published single-cell RNA sequencing data
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Human reproduction (Oxford, England), 30(8), 1867-1875 (2015-06-18)
Does peri-ovulatory putrescine supplementation of older mice improve oocyte quality and reduce the incidence of embryo resorption? Peri-ovulatory putrescine supplementation in older mice improved oocyte quality, as indicated by increased blastocyst cell numbers and reduced the incidence of embryo resorption.
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Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection
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