1.37165

Spermidine

EMPROVE^® EXPERT

• Synonim(y): Spermidine, 1,8-Diamino-4-azaoctane; N-(3-Aminopropyl)-1,4-diaminobutane, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Wzór liniowy: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Numer CAS: 124-20-9
• Masa cząsteczkowa: 145.25
• Beilstein: 1698591
• Numer MDL: MFCD00008229
• Kod UNSPSC: 12352103
• Numer indeksu EC: 204-689-0

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 500
• klasa czystości: GMO free; GMP
• opis: Aflatoxin-free; Melamin-free; DNase-free; RNase-free
• linia produktu: EMPROVE^® EXPERT
• zanieczyszczenia: low in endotoxins
• współczynnik refrakcji: n20/D 1.479 (lit.)
• wielkość cząstki: (liquid or solidified mass)
• gęstość: 0.925 g/mL at 25 °C (lit.)
• Zastosowanie: pharma/biopharma processes; pharmaceutical
• temp. przechowywania: 15-25°C
• ciąg SMILES: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Klucz InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N

Opis

Opis ogólny

Finding the right critical raw material that matches your quality expectation can be challenging. Especially if you are advancing through clinical phases, changing regulatory requirements can raise several questions.

As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Spermidine has several applications beyond its chemical behavior as a base. The amino groups can interact with the phosphate groups of DNA and RNA and stabilize them. In addition, spermidine has a positive impact on transcription by RNA polymerases and can be found in several buffers. Within RNA bioprocessing, spermidine can be used for purification to bind and precipitate DNA. It may also be considered as adjuvant for mRNA vaccines.

The EMPROVE^® Expert quality grade provided with this product is tested for microbial and endotoxin levels and is RNase- and DNase-free. Stability studies according to ICH Q7 are running and stability conclusions will be available via EMPROVE^® Suite.

Działania biochem./fizjol.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Przestroga

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H314
• Zwroty wskazujące środki ostrożności: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Klasyfikacja zagrożeń: Eye Dam. 1 - Skin Corr. 1B
• Kod klasy składowania: 8A - Combustible corrosive hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 233.6 °F - closed cup
• Temperatura zapłonu (°C): 112 °C - closed cup