553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Synonim(y):
InSolution Rapamycin, mTOR Inhibitor I
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About This Item
Wzór empiryczny (zapis Hilla):
C51H79NO13
Masa cząsteczkowa:
914.17
Kod UNSPSC:
12352200
NACRES:
NA.77
Polecane produkty
product name
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Poziom jakości
Próba
≥95% (HPLC)
Postać
solution
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
desiccated (hygroscopic)
protect from light
Warunki transportu
wet ice
temp. przechowywania
−20°C
Opis ogólny
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Działania biochem./fizjol.
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Irritant (B)
Postać fizyczna
2.5 mg/mL solution in DMSO (2.74 mM)
Rekonstytucja
Following initial use, aliquot and freeze (-20°C).
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Temperatura zapłonu (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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