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R8781

Sigma-Aldrich

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor

Synonim(y):

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution

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About This Item

Wzór empiryczny (zapis Hilla):
C51H79NO13
Masa cząsteczkowa:
914.17
Numer WE:
200-664-3
Kod UNSPSC:
12352200
NACRES:
NA.77

product name

Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

pochodzenie biologiczne

Streptomyces hygroscopicus

Poziom jakości

300

ciśnienie pary

0.56 hPa ( 20 °C)

Próba

≥95% (HPLC)

Postać

solution

temp. samozapłonu

301 °C

stężenie

2.5 mg/mL in DMSO (2.74 mM)

kolor

colorless to yellow

spektrum działania antybiotyku

fungi
yeast

Tryb działania

enzyme | inhibits

temp. przechowywania

−20°C

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Opis ogólny

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.

Zastosowanie

Rapamycin has been used:
  • as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
  • to treat the Drosophila S2 cells at 65-70% confluence,
  • to measure protein synthesis
  • to stimulate autophagy in ovarian cancer cells

Opakowanie

200uL

Inne uwagi

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.
This page may contain text that has been machine translated.

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

188.6 °F - closed cup

Temperatura zapłonu (°C)

87 °C - closed cup

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certyfikaty analizy (CoA)

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