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880120C

Avanti

18:0 PEG2000 PE

Avanti Research™ - A Croda Brand 880120C

Synonim(y):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

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About This Item

Numer CAS:
474922-77-5
Kod UNSPSC:
12352211
NACRES:
NA.25

Postać

liquid

opakowanie

pkg of 1 × 2.5 mL (880120C-25mg)
pkg of 1 × 20 mL (880120C-500mg)
pkg of 2 × 4 mL (880120C-200mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand 880120C

stężenie

10 mg/mL (880120C-25mg)
25 mg/mL (880120C-200mg)
25 mg/mL (880120C-500mg)

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

Opis ogólny

18:0 PEG2000 PE, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000], is a modified phospholipid containing a 2000-Da PEG moiety in the polar head.

Zastosowanie

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium salt (DSPE-PEG1) has been used to conjugate PEG onto residual amine groups on the surfaces of the functionalized TaO nanoparticles. DSPE-PEG1 may be used as a surfactant for homeotropic anchoring of the mesogen molecules. It may also be used in preparation of Nano formulations.

Działania biochem./fizjol.

PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to facilitate the formation of sterically stabilized liposomes (SSL). These liposomes have low reticuloendothelial system (RES) uptake and they prolong the circulating plasma half-life of the drug. The plasma half-life of the drug can be tuned from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.

Opakowanie

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (880120C-500mg)
5 mL Clear Glass Sealed Ampule (880120C-200mg)
5 mL Clear Glass Sealed Ampule (880120C-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard
GHS06,GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H302,H315,H319,H331,H336,H351,H361d,H372,H412

Klasyfikacja zagrożeń

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organy docelowe

Central nervous system, Liver,Kidney

Kod klasy składowania

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

does not flash

Temperatura zapłonu (°C)

does not flash

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly (ethylene glycol)
Kirpotin D, et al.
Febs Letters, 388(2-3), 115-118 (1996)
Encapsulated miR-200c and Nkx2. 1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells
D?Almeida O, et al.
BMC Cancer, 19(1), 136-136 (2019)
Ling Ye et al.
Nanotheranostics, 3(1), 54-65 (2019-01-22)
Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially cause reproductive toxicity even at levels that
P A Melnikov et al.
Bulletin of experimental biology and medicine (2019-11-24)
We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the
Kathleen Cullion et al.
Pharmaceutical research, 36(12), 179-179 (2019-11-11)
It is unknown whether there are sex differences in response to free or encapsulated local anesthetics. We examined nerve block duration and toxicity following peripheral nerve blockade in male and female rats. We studied the local anesthetic bupivacaine (free or
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