902314

[CpRu(Fmoc-tyrosin)]CF₃CO₂

• Synonim(y): Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor
• Wzór empiryczny (zapis Hilla): C₃₁H₂₆F₃NO₇Ru
• Masa cząsteczkowa: 682.61
• Kod UNSPSC: 12352209
• NACRES: NA.26

Właściwości

• Postać: powder
• przydatność reakcji: reaction type: Fmoc solid-phase peptide synthesis
• mp: >300 °C
• Zastosowanie: peptide synthesis
• grupa funkcyjna: Fmoc
• temp. przechowywania: 2-8°C
• ciąg SMILES: O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5

Opis

Zastosowanie

The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.

Przestroga

Research quantities limited to 10 g.

Inne uwagi

Site-SpecificDeoxyfluorination of Small Peptides with [18F]Fluoride

Informacje prawne

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable