SML3908

SLU-PP-332

≥98% (HPLC)

• 別名: (E)-4-Hydroxy-N′(naphthalen-2-ylmethylene)benzohydrazide, 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide, ERR pan-Agonist 332, SR9861
• 実験式（ヒル表記法）: C₁₈H₁₄N₂O₂
• CAS番号: 303760-60-3
• 分子量: 290.32
• MDL番号: MFCD00595076
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: 2-8°C
• SMILES記法: OC1=CC=C(C=C1)C(N/N=C/C2=CC3=C(C=C2)C=CC=C3)=O
• InChI Key: RNZIMBFHRXYRLL-XDHOZWIPSA-N

詳細

生物化学的／生理学的作用

Non-toxic pan ERRα/β/γ agonist with significant ERRα activity that acts as an exercise mimetic.



SLU-PP-332 is a non-toxic pan ERRα/β/γ (estrogen receptor-related receptors α/β/γ) agonist with significant ERRα activity (EC50 = 98, 230 & 430 nM against ERRα, ERRβ & ERγ) and acts as an exercise mimetic. SLU-PP-332 displays selectivity over ERα, ERβ and several other closely related nuclear receptors. It induces Ddit4 expression and enhances mitochondrial respiration in C2C12 myocytes (10 µM) and exercise endurance in mice (50 mg/kg bid, ip) in an ERRα-dependent manner.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable