SML3360

STM2457

≥98% (HPLC)

• 別名: N-[(6-{[(Cyclohexylmethyl)amino]methyl}imidazo[1,2-a]pyridin-2-yl)methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, STM 2457, STM-2457
• 実験式（ヒル表記法）: C₂₅H₂₈N₆O₂
• CAS番号: 2499663-01-1
• 分子量: 444.53
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O=C1C=C(C(NCC2=CN3C=C(CNCC4CCCCC4)C=CC3=N2)=O)N=C5C=CC=CN15

詳細

生物化学的／生理学的作用

STM2457 is a potent and highly selective SAM-binding site METTL3 (MT-A70) m6A methyltransferase inhibitor (IC50 = 16.9 nM, Kd = 1.4 nM by SPR, using METTL3-METTL14 complex; no potency toward other RNA/DNA/protein methyltransferases or 486 kinases). STM2457 selectively inhibits human AML proliferation (IC50 = 0.6-10.3 µM) and the clonogenic potential of primary mouse AML, but not normal mouse haematopoietic stem/progenitor or human cord blood CD34+ cells. STM2457 impairs the expansion of AML patient-derived xenografts in mice in vivo (50 mg/kg i.p.) and significantly prolongs the animal′s lifespan. STM2457 is also reported to restrict β-coronavirus replication and spread.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable