おすすめの製品
由来生物
rabbit
品質水準
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
55 kDa
交差性
rat, mouse, human
濃度
2.8 mg/mL
テクニック
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
アイソタイプ
IgG
アクセッション番号
NP_036211.2
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... DGAT1(8694)
詳細
Diacylglycerol-acyltransferase 1 (DGAT1), a transmembrane protein, is a member of the membrane-bound O-acyltransferase superfamily. It is seen in the endoplasmic reticulum of several cells. DGAT1 is ubiquitously expressed in humans. A high level of mRNA is seen in the small intestine. It has three transmembrane domains. The DGAT1 gene is mapped to human chromosome 8q24.3.
特異性
The antibody detects endogenous levels of total DGAT1 protein.
免疫原
Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1
アプリケーション
Anti-DGAT1 antibody produced in rabbit has been used in immunoblotting.
生物化学的／生理学的作用
Diacylglycerol-acyltransferase 1 (DGAT1) converts diacylglycerol and fatty acyl-CoA to triacylglycerol. It participates in energy storage. DGAT1 plays a key role in cancer progression. Activity of DGAT1 is essential for the physiologic absorption of vitamin D. Absence of DGAT1 activity is linked with body weight and adiposity reduction, and increased insulin sensitivity. Aberrations in the DGAT1 gene are associated with congenital diarrheal disorder (CDD).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4301075-100UL:
最新バージョンのいずれかを選択してください：
A Mercadé et al.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 122(3), 161-164 (2005-09-01)
DGAT1 is a microsomal enzyme that catalyses the final step in triglycerides synthesis. DGAT1-deficient mice are viable, lean, fertile and resistant to diet induced obesity. We have previously identified a quantitative trait loci (QTL) on chromosome 4 that affects fatty
Aditi Gupta et al.
European journal of medical genetics, 63(4), 103817-103817 (2019-11-30)
DGAT1, a gene encoding a protein involved in lipid metabolism, has been recently implicated in causing a rare nutritional and digestive disease presenting as Congenital Diarrheal Disorder (CDD). Genetic causes of malnutrition can be classified as metabolic disorders, caused by
Ping He et al.
BMC cancer, 21(1), 252-252 (2021-03-23)
Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissue indicated a poor outcome in cancer patients. However, the
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