MAB2637

Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1

clone HMb3-1, from hamster(Armenian)

• 別名: CD61 antigen, Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet glycoprotein IIIa, GPIIIa
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: hamster (Armenian)
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: HMb3-1, monoclonal
• 化学種の反応性: mouse
• テクニック: flow cytometry: suitable; immunohistochemistry: suitable
• アイソタイプ: IgG
• NCBIアクセッション番号: NP_058060.2
• UniProtアクセッション番号: O54890
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Itgb3(16416)

詳細

詳細

The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.

Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.

特異性

The antibody recognizes Integrin beta-3.

免疫原

Recombinant protein corresponding to mouse Integrin beta-3.

アプリケーション

Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH.

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995).

品質

Evaluated by Flow Cytometry on mouse bone marrow-derived cells.

Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells

ターゲットの説明

~ 86-87 kDa

物理的形状

Format: Purified

アナリシスノート

Control
Mouse bone marrow-derived cells

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable