M7824

メトトレキサート

• 別名: メトトレキサート, (+)-アメトプテリン, 4-アミノ-10-メチル葉酸, 4-アミノ-N¹⁰-メチルプテロイル-L-グルタミン酸, MTX, アンチフォラン, メチルアミノプテリン
• 実験式（ヒル表記法）: C₂₀H₂₂N₈O₅
• CAS番号: 59-05-2
• 分子量: 454.44
• Beilstein: 70669
• EC Number: 200-413-8
• MDL番号: MFCD00064370
• UNSPSCコード: 41116107
• NACRES: NA.21

特性

• 由来生物: synthetic
• 品質水準: 400
• フォーム: powder
• 適合性: suitable for manufacturing use
• 保管温度: −20°C
• SMILES記法: CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• InChI Key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• 遺伝子情報: human ... DHFR(1719)

詳細

詳細

Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

法的情報

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H360D,H372
• 注意書き: P202 - P260 - P264 - P280 - P301 + P310 - P405
• 危険有害性の分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• ターゲットの組織: Liver,Bone marrow
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable