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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
whole antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
含みます
15 mM sodium azide
化学種の反応性
mammals
テクニック
western blot: 1:200
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MAP2(4133) , MAPT(4137)
mouse ... Mapt(17762) , Mtap2(17756)
rat ... Map2(25595) , Mapt(29477)
詳細
Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).
特異性
Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin.
免疫原
heat stable MAPs prepared from bovine brain.
アプリケーション
Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:
- immunofluorescent labelling
- immunohistochemistry
- immunoprecipitation
- immunofluorescence staining
- western blotting
生物化学的／生理学的作用
Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
M7273-VAR:
M7273-BULK:
M7273-1ML:
M7273-.2ML:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Dynamic Instability of Microtubules Assembled from Microtubule-Associated Protein-Free Tubulin: Neither Variability of Growth and Shortening Rates nor ?Rescue? Requires Microtubule-Associated Proteins
Billger MA, et al.
Biochemistry, 35(42), 13656-13663 (1996)
The MAP2/Tau family of microtubule-associated proteins
Dehmelt L, et al.
Genome Biology, 6(1), 1-10 (2005)
Increased Phosphorylation of Ca/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation
Fukunaga K, et al.
Test, 270(11), 6119-6124 (1995)
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons
Coughlan CM, et al.
Neuroscience, 97(3), 591-600 (2000)
J H Holstein et al.
British journal of pharmacology, 154(5), 1055-1062 (2008-05-06)
The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF
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