1.04354

L-ヒスチジン 一塩酸塩 一水和物

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP

• 別名: L-α-アミノ-β-(4-イミダゾリル)プロピオン酸 一塩酸塩
• 実験式（ヒル表記法）: C₆H₉N₃O₂ · HCl · H₂O
• CAS番号: 5934-29-2
• 分子量: 209.63
• Beilstein: 4168261
• MDL番号: MFCD00151027
• UNSPSCコード: 12352107
• EC Index Number: 211-438-9

特性

• 認証: BP; ChP; JP; Ph. Eur.
• 品質水準: 500
• 蒸気圧: <1 hPa ( 20 °C)
• 製品種目: EMPROVE^® EXPERT
• アッセイ: 98.5-101.0% (alkalimetric); 99.0-101.0% (perchloric acid titration)
• 形状: solid
• pH: 3.5-4.5 (20 °C, 100 g/L in H₂O)
• mp: 254 °C (dec.) (lit.)
• 溶解性: 149.55 g/L
• 密度: 1.49 g/cm³ at 20 °C
• アプリケーション: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 保管温度: 2-30°C
• SMILES記法: O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
• InChI Key: CMXXUDSWGMGYLZ-XRIGFGBMSA-N

詳細

詳細

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove^® Expert is especially suitable for high-risk applications.

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable