1.01544

L-アルギニン 一塩酸塩

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• 別名: (S)-(+)-2-アミノ-5-[(アミノイミノメチル)アミノ]ペンタン酸 一塩酸塩, (S)-(+)-アルギニン 塩酸塩
• 実験式（ヒル表記法）: C₆H₁₄N₄O₂ · HCl
• CAS番号: 1119-34-2
• 分子量: 210.66
• Beilstein: 3631658
• MDL番号: MFCD00064550
• UNSPSCコード: 12352209
• EC Index Number: 214-275-1

特性

• 認証: BP; ChP; JP; Ph. Eur.; USP
• 品質水準: 500
• 蒸気圧: <1 Pa ( 20 °C)
• 製品種目: EMPROVE^® EXPERT
• アッセイ: 98.5-101.0% dry basis (perchloric acid titration)
• 形状: solid
• pH: 5.7 (20 °C, 100 g/L in H₂O)
• mp: >235 °C
• 溶解性: water: 730 g/L at 20 °C
• 密度: 1.42 g/cm³ at 20 °C
• 微量陰イオン: chloride (Cl^-): 16.5-17.1%; sulfate (SO₄^2-): ≤200 ppm
• 微量陽イオン: As: ≤2 ppm; Fe: ≤10 ppm; NH₄⁺: ≤200 ppm; heavy metals (as Pb): ≤10 ppm
• アプリケーション: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 保管温度: 2-30°C
• SMILES記法: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI Key: KWTQSFXGGICVPE-WCCKRBBISA-N

詳細

詳細

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove^® Expert is suitable for high-risk applications.

生物化学的／生理学的作用

一酸化窒素シンターゼの基質で、シトルリンと一酸化窒素(NO)に転換されます。一酸化窒素依存的な機序によってインスリンの放出を誘導します。

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable