916978

BocA1V2PF1

≥95%

• 別名: ((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-2-cyclohexylacetyl)-L-prolyl-L-phenylalanine, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
• 実験式（ヒル表記法）: C₃₀H₄₄N₄O₇
• 分子量: 572.69
• MDL番号: MFCD33021749
• UNSPSCコード: 41116105
• NACRES: NA.22

特性

• ligand: BocA1V2PF1
• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder
• 反応適合性: reagent type: ligand
• 官能基: carboxylic acid
• 保管温度: 2-8°C
• SMILES記法: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O
• InChI: 1S/C30H44N4O7/c1-19(31-29(40)41-30(2,3)4)25(35)33-24(21-14-9-6-10-15-21)27(37)34-17-11-16-23(34)26(36)32-22(28(38)39)18-20-12-7-5-8-13-20/h5,7-8,12-13,19,21-24H,6,9-11,14-18H2,1-4H3,(H,31,40)(H,32,36)(H,33,35)(H,38,39)/t19-,22-,23-,24-/m0/s1
• InChI Key: HVORUACRMULJRJ-HCUBDLJJSA-N

詳細

アプリケーション

BocA1V2PF1 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V2PF1 is also available as A1V2PF1-NHEt (917222).

BocA1V2PF1 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks
917966 BocA1V2PF1-NHC₆-NH₂
916706 BocA1V2PF1-NHC₁₀-NH₂
916951 BocA1V2PF1-NHPEG₁-NH₂
917214 BocA1V2PF1-NHPEG₃-NH₂

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

その他情報

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable