917923

A1V1PF2-OEt-PEG₁-NH₂ hydrochloride

• 別名: AVP conjugate for IAP-mediated protein degrader development, Ethyl (S)-2-((S)-1-((S)-2-((S)-2-((2-(2-aminoethoxy)ethyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate hydrochloride, SNIPER building block
• 実験式（ヒル表記法）: C₂₉H₄₆FN₅O₆ · xHCl
• 分子量: 579.70 (free base basis)
• MDL番号: MFCD34549903
• UNSPSCコード: 41116105
• NACRES: NA.22

特性

• ligand: A1V1PF2
• 品質水準: 100
• フォーム: powder
• 反応適合性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 保管温度: 2-8°C
• SMILES記法: C[C@H](NCCOCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
• InChI: 1S/C29H46FN5O6.ClH/c1-6-41-28(39)22(18-20-9-11-21(30)12-10-20)33-26(37)23-8-7-15-35(23)27(38)24(29(3,4)5)34-25(36)19(2)32-14-17-40-16-13-31;/h9-12,19,22-24,32H,6-8,13-18,31H2,1-5H3,(H,33,37)(H,34,36);1H/t19-,22-,23-,24+;/m0./s1
• InChI Key: QJQSVDCTXDWZTC-YHPWAZSSSA-N

詳細

アプリケーション

Protein degrader building block A1V1PF2-OEt-PEG₁-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^® degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
917710 A1V1PF2-OEt
917427 A1V1PF2-OEt-C₆-NH₂ hydrochloride
917672 A1V1PF2-OEt-C10-NH₂ hydrochloride
917923 A1V1PF2-OEt-PEG₁-NH₂ hydrochloride
916676 A1V1PF2-OEt-PEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

その他情報

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable