SML2950

E7820

≥98% (HPLC)

• 別名: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
• 実験式（ヒル表記法）: C₁₇H₁₂N₄O₂S
• CAS番号: 289483-69-8
• 分子量: 336.37
• MDL番号: MFCD09833234
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• ligand: E7820
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 反応適合性: reagent type: ligand
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• InChI: 1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
• InChI Key: LWGUASZLXHYWIV-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

E7820 (NSC 719239) is an orally available anticancer and antiangiogenic agent that inhibits VEGF-2 or FGF-2-induced tube formation of HUVEC cells through the suppression of integrin α2. E7820 promotes selective proteasomal degradation of the U2AF-related splicing factor CAPERα (coactivator of activating protein-1 and estrogen receptors) by ubiquitination and degradation via CRL4DCAF15.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable