907367

Fmoc-L-photo-methionine

≥95%, for peptide synthesis

• 別名: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid, (S)-2-(Fmoc-amino)-4-(3H-diazirin-3-yl)pentanoic acid, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• 実験式（ヒル表記法）: C₂₁H₂₁N₃O₄
• CAS番号: 945859-89-2
• 分子量: 379.41
• MDL番号: MFCD31380717
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 製品名: Fmoc-L-photo-methionine, ≥95%
• アッセイ: ≥95%
• フォーム: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• アプリケーション: peptide synthesis
• 官能基: Fmoc
• 保管温度: −20°C
• SMILES記法: N([C@@H](CCC4(N=N4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI Key: QKMQUEIDJLPYHS-SFHVURJKSA-N

詳細

アプリケーション

Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

その他情報

Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers ′

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Covalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-Linker

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable