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品質水準
アッセイ
98%
mp
60-62 °C (lit.)
官能基
bromo
ketone
保管温度
2-8°C
SMILES記法
COc1cccc(c1)C(=O)CBr
InChI
1S/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
InChI Key
IOOHBIFQNQQUFI-UHFFFAOYSA-N
関連するカテゴリー
アプリケーション
2-bromo-3′-methoxyacetophenone, an alkylating agent, has been used to stabilize clopidogrel active metabolite (AM) in human plasma. It has also been used in the derivatisation of active metabolites in blood to ensure its stability during sample processing and storage.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
8A - Combustible corrosive hazardous materials
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
115673-10G:
115673-1KG:
115673-1G:
115673-VAR:
115673-BULK:
115673-25G:
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Jinfang Jiang et al.
Frontiers in pharmacology, 8, 846-846 (2017-12-07)
Vicagrel, a structural analog of clopidogrel, is now being developed as a thienopyridine antiplatelet agent in a phase II clinical trial in China. Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite
Makoto Takahashi et al.
Journal of pharmaceutical and biomedical analysis, 48(4), 1219-1224 (2008-10-03)
A quantitative method for the determination of clopidogrel active metabolite (AM) in human plasma was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Clopidogrel AM contains a thiol group, thus requiring stabilization in biological samples. The alkylating reagent 2-bromo-3'-methoxyacetophenone
Nagy A Farid et al.
Rapid communications in mass spectrometry : RCM, 21(2), 169-179 (2006-12-13)
Two fast and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based bioanalytical assays were developed and validated to quantify the active and three inactive metabolites of prasugrel. Prasugrel is a novel thienopyridine prodrug that is metabolized to the pharmacologically active metabolite in
Ting Tai et al.
Journal of pharmaceutical and biomedical analysis, 179, 112955-112955 (2019-12-24)
Vicagrel is a promising novel antiplatelet drug. However, the quantification of vicagrel in plasma is currently unavailable since it is liable to be hydrolyzed in plasma by esterases. In this study, an optimized strategy was developed and validated to stabilize
Jin-Zi Ji et al.
Biochemical pharmacology, 183, 114313-114313 (2020-11-03)
Variability in P-glycoprotein (P-gp) efflux transporting activity was supposed to be involved in altered intestinal absorption and bioavailability of clopidogrel in patients; however, reliable evidence is still lacking. In this study, we sought to determine whether P-gp could play an
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