推荐产品
生物源
bacterial (Flavobacterium heparinum)
品質等級
共軛
(Glucosaminoglycan)
形狀
lyophilized powder (with BSA as stabilizer)
運輸包裝
dry ice
儲存溫度
−20°C
應用
来自Sigma的酶已用于分析硫酸皮肤素十二糖中艾杜糖醛酸的频率。它也被用于消化黑素瘤细胞中的硫酸皮肤素（DS）。这种消化导致癌细胞的增殖和侵袭性降低，从而显示了DS在转移中的作用。
来自肝素黄杆菌的软骨素酶B已用于评估硫酸皮肤素的结构表征和抗凝血酶活性的研究中。肝素黄杆菌的软骨素酶B也已用于通过液相色谱-质谱法研究软骨素裂解酶的作用方式的研究中。
生化／生理作用
软骨素酶B仅降解硫酸软骨素B，产生寡糖和四糖，以及不饱和的4-硫酸二糖。它的最佳温度为20℃，最佳pH值为8.0。使用0.1 M NaCl可将酶活性抑制50%。Co2+、Fe3+和Ba2+也抑制其活性。
單位定義
使用硫酸软骨素B作为底物，在25℃和pH 7.5下，一个单位每小时将形成0.1 μmole不饱和糖醛酸。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Gerdy B ten Dam et al.
The American journal of pathology, 171(4), 1324-1333 (2007-08-25)
Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor development. We applied the phage display technology to select antibodies that identify these tumor-specific CS modifications. Antibody GD3G7 was
Y M Michelacci et al.
The Biochemical journal, 151(1), 121-129 (1975-10-01)
A chondroitinase that degrades only chondroitin sulphate B was isolated from Flavobacterium heparinum, and separated from a constitutive chondroitinase AC also present in extracts of F. heparinum. The enzyme acts only on chondroitin sulphate B, producing oligo- and tetra-saccharides, plus
Zhenqing Zhang et al.
Analytical biochemistry, 385(1), 57-64 (2008-11-11)
Liquid chromatography-mass spectrometry was applied to determine the action pattern of different chondroitin lyases. Two commercial enzymes, chondroitinase ABC (Proteus vulgaris) and chondroitinase ACII (Arthrobacter aurescens), having action patterns previously determined by viscosimetry and gel electrophoresis were first examined. Next
Nicola Volpi et al.
Glycobiology, 19(4), 356-367 (2008-12-06)
Glycosaminoglycans from the body of marine clam Scapharca inaequivalvis were extracted at about 0.15- 0.18 mg/g of dry tissue, composed of dermatan sulfate (DS) (approx. 74%) and heparan sulfate (26%). After treatment with nitrous acid, DS was isolated for further
Yvette M Coulson-Thomas et al.
Journal of neuroscience methods, 171(1), 19-29 (2008-04-18)
Injury to the CNS of vertebrates leads to the formation of a glial scar and production of inhibitory molecules, including chondroitin sulphate proteoglycans. Various studies suggest that the sugar component of the proteoglycan is responsible for the inhibitory role of
商品
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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