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應用
来自牛肾的硫酸乙酰肝素钠盐已被用于：
- 研究其对B细胞增殖的作用
- 监测其在E5胚胎细胞中眼睛发育中的作用
- 通过斑点印迹研究其与人小梁网状细胞中外泌体纤连蛋白的结合。
生化／生理作用
硫酸乙酰肝素（HS）是一种普遍存在的糖胺聚糖，是D-葡萄糖醛酸或L-艾杜糖醛酸与D-葡萄糖胺（GlcA）糖的聚合物。它是在顺式高尔基体中以肝素形式合成的。在高尔基体中，最终的硫酸乙酰肝素是通过N-和O-HS-硫转移酶以及HS差向异构酶的作用而合成的。成熟的HS具有50至200个二糖单元。它是细胞外基质（ECM）的一部分并在致癌途径中起关键作用。硫酸肝素代谢的失调与癌症的进展有关。HS与感染性疾病和炎性疾病的发作有关。HS与Aβ淀粉样纤维作用，与阿兹海默症′有关。硫酸乙酰肝素是膜结合蛋白聚糖的组成成分，具有细胞黏附作用。
膜相关蛋白聚糖的组成被认为有助于细胞间的粘附
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Y Tanaka et al.
The Journal of experimental medicine, 184(5), 1987-1997 (1996-11-01)
Leukocyte migration from circulation into tissue depends on leukocyte integrin-mediated adhesion to endothelium, but integrins cannot function until activated. However, it remains to be understood how tumor cells adhere to endothelium and infiltrate into underlying tissue. We studied mechanisms of
K Fuxe et al.
Brain research, 746(1-2), 25-33 (1997-01-23)
In the present paper immunocytochemical analysis at the fluorescence microscopical level has been performed of neural cell adhesion. molecule (NCAM) immunoreactivity in the adult rat tel- and diencephalon in order to further substantiate the highly selective neuronal localization of NCAM
Molecular diversity of heparan sulfate
Esko JD and Lindahl Ulf
The Journal of Clinical Investigation, 108(2), 169-173 (2001)
Mechanism of fibronectin binding to human trabecular meshwork exosomes and its modulation by dexamethasone
Dismuke WM, et al.
Testing, 11(10), e0165326-e0165326 (2016)
Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer?s disease
Zhang GL, et al.
BioMed Research International, 2014(6), 555-571 (2014)
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There are five identified glycosaminoglycan chains (see Figure 1): Hyaluronan is not sulfated, but the other glycosaminoglycan chains contain sulfate substituents at various positions of the chain.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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