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一般說明
肝素是一种糖胺聚糖 (GAG),属于粘多糖家族,以其有效的抗凝特性而闻名。这种广泛硫酸化的多糖由通过糖苷键连接的 D-葡萄糖胺和己糖醛酸组成。它广泛应用于各类生化研究和细胞培养研究。
應用
培养基中加入猪肠粘膜来源的肝素钠盐,用于精子对卵母细胞的授精猪肠粘膜来源的肝素钠盐可用于:
- 检查肝素对 FGF21(成纤维细胞生长因子 21)信号传导的影响。
- 对小鼠脑切片进行免疫染色
- 定量金鲷(Sparus aurata)血液样本中的白细胞和红细胞
- 用于抗凝和严重急性呼吸综合征冠状病毒 2 (SARS-CoV2) 抑制测定
生化/生理作用
肝素主要负责延迟血液凝固。它可增强抗凝血酶介导的蛋白酶失活。
肝素在肥大细胞和组胺等介质中合成,与过敏和炎症活动相关。肝素对静脉血栓和肺栓塞表现出治疗作用,有助于预防溶栓后的再血栓形成,并可控制急性心肌梗塞患者的动脉血栓形成。肝素在许多炎症性疾病中表现出抗炎作用,如烧伤、支气管哮喘和溃疡性结肠炎。
肝素在肥大细胞和组胺等介质中合成,与过敏和炎症活动相关。肝素对静脉血栓和肺栓塞表现出治疗作用,有助于预防溶栓后的再血栓形成,并可控制急性心肌梗塞患者的动脉血栓形成。肝素在许多炎症性疾病中表现出抗炎作用,如烧伤、支气管哮喘和溃疡性结肠炎。
其他說明
肝素溶液不可高压灭菌,因为高温下可能会发生额外的糖交联。它也不可冻结。
推薦產品
用于诊断制造的肝素产品编号为 SRE0027
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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