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生物源
Porcine intestinal mucosa
品質等級
化驗
≥90%
形狀
lyophilized powder
雜質
≤20% water (Karl Fischer)
顏色
white
溶解度
H2O: 5 mg/mL, clear, colorless
正離子痕跡
Na: 7.0-11.5%
儲存溫度
2-8°C
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相关类别
一般說明
软骨素是一种糖胺聚糖(GAG)，是N-乙酰半乳糖胺(GalNAc)和葡萄糖醛酸(GlcA)交替单元组成的多糖链，可以在GalNAc和GlcA其中一个单元或两个单元上发生硫酸化。软骨素及其硫酸盐经常与蛋白质结合形成蛋白多糖。硫酸软骨素B（硫酸软骨素）是蛋白聚糖的组分，例如核心蛋白聚糖，双糖链蛋白聚糖和多功能蛋白聚糖。硫酸软骨素B用于研究 β 肽（1-42）的细胞毒性。
應用
硫酸软骨素B可用于研究其作为生物分子受体、细胞信号传导和细胞结合分子的介质的作用。它可用于与硫酸软骨A和硫酸软骨素C的性质进行比较。硫酸软骨素B用于研究 β 肽（1-42）的细胞毒性。
生化／生理作用
作为一种大的带负电荷亲水性分子，硫酸软骨素分子不足以灵活折叠成紧密的球状结构，而是形成多孔水合凝胶，为组织提供机械支持，并允许水溶性分子的快速扩散和细胞迁移。
成分
硫酸软骨素B是在软骨、皮肤、角膜和脐带中发现的酸性粘多糖。 它由交替的N-乙酰半乳糖胺，L-艾杜糖醛酸和等摩尔量的硫酸盐残基组成，其中N-乙酰半乳糖胺的4位碳被硫酸化。
注意
请将该产品储存在2-8°C。
準備報告
将本产品 100 mg/mL的浓度溶于水。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Ana M Saraiva et al.
Macromolecular bioscience, 10(10), 1152-1163 (2010-05-19)
The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched
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Current Alzheimer research, 7(5), 428-438 (2010-01-02)
One mechanism leading to neurodegeneration during Alzheimer's disease (AD) is amyloid beta peptide (Abeta)-induced neurotoxicity. Among the factors proposed to potentiate Abeta toxicity is its covalent modification through carbohydrate-derived advanced glycation endproducts (AGEs). Other experimental evidence, though, indicates that certain
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International journal of molecular sciences, 19(6) (2018-06-09)
Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects
商品
There are five identified glycosaminoglycan chains (see Figure 1): Hyaluronan is not sulfated, but the other glycosaminoglycan chains contain sulfate substituents at various positions of the chain.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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