V9389
Violacein
from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC), powder, bacterial metabolite
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About This Item
Fórmula empírica (Notação de Hill):
C20H13N3O3
Número CAS:
Peso molecular:
343.34
Código UNSPSC:
12352200
NACRES:
NA.77
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Nome do produto
Violacein from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
Nível de qualidade
Ensaio
>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
solubilidade
H2O: insoluble
acetone: soluble
ethanol: soluble
methanol: soluble
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
N1C(=C\C(=C4/c5c(cccc5)NC/4=O)\C1=O)c2c3c([nH]c2)ccc(c3)O
InChI
1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13-
chave InChI
XAPNKXIRQFHCHN-AQTBWJFISA-N
Descrição geral
Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics. It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.
Aplicação
Violacein from Janthinobacterium lividum has been used:
- for cell culture assays
- as a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 cultures
- as a standard to identify violacein in the leaf samples of Nicotiana
Ações bioquímicas/fisiológicas
Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities.
Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Yee Meng Chong et al.
Journal of natural products, 74(10), 2261-2264 (2011-09-14)
A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026
Adnan Ahmetagic et al.
Plasmid, 66(3), 152-158 (2011-08-16)
Bacterial plasmids and phages encode the synthesis of toxic molecules that inhibit protozoan predation. One such toxic molecule is violacein, a purple pigmented, anti-tumour antibiotic produced by the Gram-negative soil bacterium Chromobacterium violaceum. In the current experiments a range of
High-level production of violacein by the newly isolated Duganella violaceinigra str. NI28 and its impact on Staphylococcus aureus
Choi SY, et al.
Scientific reports, 5, 15598-15598 (2015)
Wan Azlina Ahmad et al.
Applied biochemistry and biotechnology, 167(5), 1220-1234 (2012-01-27)
The present work highlighted the production of violacein by the locally isolated Chromobacterium violaceum (GenBank accession no. HM132057) in various agricultural waste materials (sugarcane bagasse, solid pineapple waste, molasses, brown sugar), as an alternative to the conventional rich medium. The
Sybiya Vasantha Packiavathy Issac Abraham et al.
Archives of medical research, 42(8), 658-668 (2012-01-10)
Emergence of antibiotic resistance among bacterial pathogens often leads to the failure of existing antibiotics to treat bacterial infections; thus, there is a need to seek alternative treatment measures. The aim of this study was to evaluate the anti-quorum sensing
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