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P0046

Sigma-Aldrich

Pyocyanin

from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine

Sinônimo(s):

5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

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About This Item

Fórmula empírica (Notação de Hill):
C13H10N2O
Número CAS:
85-66-5
Peso molecular:
210.23
Número MDL:
MFCD01794662
Código UNSPSC:
12352200
ID de substância PubChem:
329819996
NACRES:
NA.77

product name

Pyocyanin, from Pseudomonas aeruginosa, ≥98% (HPLC)

fonte biológica

Pseudomonas aeruginosa

Nível de qualidade

200

Ensaio

≥98% (HPLC)

forma

solid

solubilidade

DMSO: soluble
acetone: soluble
chloroform: soluble
ethanol: soluble

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CN1c2ccccc2N=C3C(=O)C=CC=C13

InChI

1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3

chave InChI

YNCMLFHHXWETLD-UHFFFAOYSA-N

Aplicação

Pyocyanin has been used as a biomarker to detect Pseudomonas aeruginosa.

Ações bioquímicas/fisiológicas

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

Nota de preparo

For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H319

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections
Alatraktchi F, et al.
Nanomedicine (London, England), 11(16), 2185-2195 (2016)
Pseudomonas aeruginosa Can Be Detected in a Polymicrobial Competition Model Using Impedance
Ward AC, et al.
PLoS ONE, 9(3), e91732-e91732 (2014)
Sheila Pourali Dogaheh et al.
Veterinary immunology and immunopathology, 237, 110265-110265 (2021-05-15)
Severe equine asthma is characterized by airway hyperresponsiveness, neutrophilic inflammation and structural alterations of the lower airways. In asthmatic horses with neutrophilic inflammation, there is insensitivity to corticosteroids characterized by the persistence of neutrophils within the airways with therapy. We
Theerthankar Das et al.
Frontiers in microbiology, 8, 2429-2429 (2018-01-10)
Pyocyanin secreted by
Mariola Andrejko et al.
Acta biochimica Polonica, 66(1), 91-100 (2019-03-05)
Thermally induced unfolding and renaturation capability of alkaline proteases (AprA) of three Pseudomonas aeruginosa strains, i.e. ATCC 27853 and two clinical isolates, was examined. Sequence analyses demonstrated a high level of aprA genes identity (99.24-99.8%) in these bacterial strains. The
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