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Key Documents

SML0982

Sigma-Aldrich

Astaxanthin

from Blakeslea trispora, ≥97% (HPLC), powder, PPARγ

Sinônimo(s):

3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin

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About This Item

Fórmula empírica (Notação de Hill):
C40H52O4
Número CAS:
Peso molecular:
596.84
Código UNSPSC:
12352200
NACRES:
NA.77

product name

Astaxanthin, ≥97% (HPLC), from Blakeslea trispora

fonte biológica

Blakeslea trispora

Nível de qualidade

Ensaio

≥97% (HPLC)

forma

powder

condição de armazenamento

desiccated
protect from light

cor

, pink to very dark purple

solubilidade

DMSO: 1 mg/mL (warmed)

temperatura de armazenamento

−20°C

InChI

1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1

chave InChI

MQZIGYBFDRPAKN-UWFIBFSHSA-N

Descrição geral

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.

Aplicação

Astaxanthin has been used:
  • as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth
  • to study its effects on the treatment of diabetic retinopathy.
  • to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.

Ações bioquímicas/fisiológicas

In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease. Due to its bright red colour, AST has been used as a food colorant in animal feeds.
Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

Outras notas

Light and air sensitive

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study.
Fu D and Tian X, et al.
Biomedical Research, 28(15) (2017)
Huilin Liu et al.
Marine drugs, 17(3) (2019-03-22)
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. It is a complex process, including a broad spectrum of hepatic lesions from fibrosis to cirrhosis. Our previous study suggested that astaxanthin (AST) could alleviate the hepatic
Epigenetic CpG methylation of the promoter and reactivation of the expression of GSTP1 by Astaxanthin in human prostate LNCaP cells.
Yang Y, et al.
The AAPS Journal, 19(2), 421-430 (2017)
Shreya Agrawal et al.
Plant physiology (2021-10-09)
The high-value carotenoid astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione) is one of the most potent antioxidants in nature. In addition to its large-scale use in fish farming, the pigment has applications as a food supplement and an active ingredient in cosmetics and in pharmaceuticals
Effects of astaxanthin on Brachionus manjavacas (Rotifera) population growth.
Johnston R K, et al.
Aquaculture Research, 49(6), 2278-2287 (2018)

Protocolos

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

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