T7204

Toremifene citrate salt

≥98% (HPLC)

• Sinônimo(s): (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, Acapodene, Fareston, GTx 006, Z-Toremifene
• Fórmula empírica (Notação de Hill): C₂₆H₂₈ClNO · C₆H₈O₇
• Número CAS: 89778-27-8
• Peso molecular: 598.08
• Número MDL: MFCD01729016
• Código UNSPSC: 51111800
• ID de substância PubChem: 329826860
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: >10 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3
• InChI: 1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• chave InChI: IWEQQRMGNVVKQW-OQKDUQJOSA-N
• Informações sobre genes: human ... ESR1(2099) , ESR2(2100)

Descrição

Descrição geral

Toremifene is a triphenylethylene derivative. It exhibits antitumor and antiestrogen effects. Toremifene has estrogen-agonist effects on blood lipids and endometrium.

Aplicação

Toremifene citrate salt has been used:

• in cell-based ELISA
• as a positive control to detect its antiviral activity against Ebola virus (EBOV)
• to treat MCF7 and T47D breast cancer cell lines

Ações bioquímicas/fisiológicas

Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.

Características e benefícios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Informações de segurança

• Pictogramas: GHS05,GHS07,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302,H318,H410
• Declarações de precaução: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable