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T6069

Sigma-Aldrich

Thio-TEPA

Sinônimo(s):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Fórmula empírica (Notação de Hill):
C6H12N3PS
Número CAS:
52-24-4
Peso molecular:
189.22
Número CE:
200-135-7
Número MDL:
MFCD00145452
Código UNSPSC:
51102829
ID de substância PubChem:
24900346
NACRES:
NA.85

Formulário

solid

Nível de qualidade

200

condição de armazenamento

(Keep container tightly closed in a dry and well-ventilated place.)

cor

white

espectro de atividade do antibiótico

neoplastics

Modo de ação

DNA synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

chave InChI

FOCVUCIESVLUNU-UHFFFAOYSA-N

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Descrição geral

Chemical structure: aziridine

Aplicação

A polyfunctional alkylating agent

Ações bioquímicas/fisiológicas

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Nota de análise

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H300,H350

Classificações de perigo

Acute Tox. 2 Oral - Carc. 1B

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
SLBZ3176
SLBV7203
SLBT6441
SLBQ8871V
SLBN5332V

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