T5050

Transforming Growth Factor-β1 from porcine platelets

≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture

• Sinônimo(s): TGF-β1
• Número MDL: MFCD00166089
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• product name: Transforming Growth Factor-β1 from porcine platelets, TGF-β1, powder, suitable for cell culture
• fonte biológica: Porcine (Platelets)
• Nível de qualidade: 100
• Ensaio: ≥97% (SDS-PAGE)
• forma: powder
• potência: 0.01-0.1 ng/mL ED₅₀/EC₅₀
• qualidade: endotoxin tested
• peso molecular: protein 25 kDa
• embalagem: pkg of 1 μg; pkg of 10 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• técnica(s): cell culture | mammalian: suitable
• Impurezas: ≤1 EU/μg
• nº de adesão UniProt: P07200
• temperatura de armazenamento: −20°C
• Informações sobre genes: pig ... TGFB1(397078)

Descrição

Descrição geral

The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.

Aplicação

Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.

Ações bioquímicas/fisiológicas

Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.

Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.

forma física

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.

Nota de análise

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)