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Documentos Principais

SRP6552

Sigma-Aldrich

TGF-β3 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Sinônimo(s):

Transforming growth factor beta-3

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

mouse

recombinante

expressed in E. coli

Ensaio

≥98% (SDS-PAGE)

Formulário

liquid

peso molecular

25.5 kDa

embalagem

pkg of 5 μg
pkg of 50 μg
pkg of 500 μg

concentração

0.25 mg/mL

Impurezas

≤1 EU/μg endotoxin (LAL test)

nº de adesão UniProt

P04202 

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

mouse ... TGF-beta-1(21803)

Categorias relacionadas

Descrição geral

TGFβ3 (transforming growth factor β3) is one of the three isoforms of mammalian TGFβ, and all the isoforms share high sequence similarity at the active domains, with TGFβ3 showing highest similarity with TGFβ1.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.
The TGFB1 gene is mapped to human chromosome 19q13.2. The encoded protein is an anti-inflammatory cytokine.

Ações bioquímicas/fisiológicas

TGFβ3 (transforming growth factor β3) shows higher expression levels during late stage tumors, and hence, is thought to be associated with tumorigenesis. However, studies also show that in skin, breast, oral and gastric mucosa and other types of tissue, this protein confers protection against tumorigenesis. It plays crucial role in the development of systems such as heart, breast and lung. It is essential for mouse embryonic palate fusion, as inactivation results in non-fusion of palatal shelves. This protein plays a crucial role in orofacial development and is essential for excisional wound repair in vivo.

forma física

0.25 mg/mL solution containing 20% ethanol and 0.12% acetic acid (AcOH) .

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash

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Certificados de análise (COA)

Lot/Batch Number

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Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
Sznurkowska K, et al.
Acta Biochimica Polonica, 65(1), 1908-1916 (2018)
TGF-beta3 and cancer: a review.
Laverty HG et al
Cytokine & Growth Factor Reviews, 20(4), 305-317 (2009)
Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Le M et al
PLoS ONE, 7(10), e48040-e48040 (2012)
Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
Begum A, et al.
Cancer Science, 100(10), 1908-1916 (2009)
Zhaoyang Liu et al.
PLoS genetics, 15(10), e1008096-e1008096 (2019-10-28)
Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma and the accumulation of pathology during aging. While genetic defects have also been associated with disc degeneration
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